Active Ingredient: Primidone
Primidone is indicated in the management of grand mal and psychomotor (temporal lobe) epilepsy. It is also of value in the management of focal or Jacksonian seizures, myoclonic jerks and akinetic attacks.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
125 - 1,500 mg
From 62.5 To 750 mg 2 time(s) per day every day
Treatment must always be planned on an individual basis. In many patients it will be possible to use primidone alone, but in some, primidone will need to be combined with other anticonvulsants or with supporting therapy.
Primidone is usually given twice daily and may be administered using either the 50 mg or 250 mg strength tablets.
Begin with 125 mg once daily late in the evening. Every 3 days increase the daily dosage by 125 mg until the patient is receiving 500 mg daily. Thereafter, every 3 days increase the daily dosage by 250 mg in adults or 125 mg in children under 9 years – until control is obtained or the maximum tolerated dosage is being given. This may be as much as 1.5 g a day in adults; 1 g a day in children.
Average daily maintenance doses:
| Milligrams | |
|---|---|
| Adults and children over 9 years | 750 to 1500 |
| Children 6 to 9 years | 750 to 1000 |
| Children 2 to 5 years | 500 to 750 |
| Children up to 2 years | 250 to 500 |
The total daily dose is usually best divided and given in two equal amounts, one in the morning and the other in the evening. In certain patients, it may be considered advisable to give a larger dose when the seizures are more frequent. For instance: 1) if the attacks are nocturnal then all or most of the day’s dose may be given in the evening; 2) if the attacks are associated with some particular event such as menstruation, a slight increase in the appropriate dose is often beneficial.
It is advisable to monitor elderly patients with reduced renal function who are receiving primidone.
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