Benign prostatic hyperplasia

Active Ingredient: Tadalafil

Indication for Tadalafil

Population group: men, only adults (18 years old or older)
Therapeutic intent: Curative procedure

Treatment of the signs and symptoms of benign prostatic hyperplasia in adult males.

For this indication, competent medicine agencies globally authorize below treatments:

5 mg once daily

For:

Dosage regimens

Oral, 5 milligrams tadalafil, once daily.

Detailed description

The recommended dose is 5 mg, taken at approximately the same time every day with or without food. For adult men being treated for both benign prostatic hyperplasia and erectile dysfunction the recommended dose is also 5 mg taken at approximately the same time every day. Patients who are unable to tolerate tadalafil 5 mg for the treatment of benign prostatic hyperplasia should consider an alternative therapy as the efficacy of tadalafil 2.5mg for the treatment of benign prostatic hyperplasia has not been demonstrated.

Dosage considerations

To be taken at approximately the same time every day with or without food.

Active ingredient

Tadalafil

Tadalafil is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by tadalafil produces increased levels of cGMP in the corpus cavernosum. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. The effect of PDE5 inhibition on cGMP concentration in the corpus cavernosum is also observed in the smooth muscle of the prostate, the bladder and their vascular supply. The resulting vascular relaxation increases blood perfusion which may be the mechanism by which symptoms of benign prostatic hyperplasia are reduced.

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