Active Ingredient: Natalizumab
Natalizumab is indicated as single disease modifying therapy in adults with highly active relapsing remitting multiple sclerosis for the following patient groups:
or
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
300 - 300 mg
From 300 To 300 mg once every 28 day(s)
Natalizumab 300 mg is administered by intravenous infusion once every 4 weeks.
Continued therapy must be carefully reconsidered in patients who show no evidence of therapeutic benefit beyond 6 months.
Data on the safety and efficacy of natalizumab at 2 years were generated from controlled, double–blind studies. After 2 years continued therapy should be considered only following a reassessment of the potential for benefit and risk. Patients should be re-informed about the risk factors for PML, like duration of treatment, immunosuppressant use prior to receiving natalizumab and the presence of anti-John Cunningham virus (JCV) antibodies.
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