Active Ingredient: Pirfenidone
Pirfenidone is indicated in adults for the treatment of mild to moderate idiopathic pulmonary fibrosis (IPF).
For this indication, competent medicine agencies globally authorize below treatments:
Oral
801 - 2,403 mg
From 267 To 801 mg 3 time(s) per day every day
Upon initiating treatment, the dose should be titrated to the recommended daily dose of nine capsules per day over a 14-day period as follows:
The recommended maintenance daily dose of Esbriet is three 267 mg capsules three times a day with food for a total of 2,403 mg/day.
Doses above 2403 mg/day are not recommended for any patient.
Patients who miss 14 consecutive days or more of Esbriet treatment should re-initiate therapy by undergoing the initial 2-week titration regimen up to the recommended daily dose.
For treatment interruption of less than 14 consecutive days, the dose can be resumed at the previous recommended daily dose without titration.
It should be taken with food to reduce the possibility of nausea and dizziness.
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