Active Ingredient: Tivozanib
Tivozanib is indicated for the first line treatment of adult patients with advanced renal cell carcinoma (RCC) and for adult patients who are VEGFR and mTOR pathway inhibitor-naïve following disease progression after one prior treatment with cytokine therapy for advanced RCC.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
1,340 - 1,340 ug
From 1,340 To 1,340 ug once every day
The recommended dose of tivozanib is 1340 microgram once daily for 21 days, followed by a 7-day rest period to comprise one complete treatment cycle of 4 weeks.
This treatment schedule should be continued until disease progression or unacceptable toxicity.
No more than one dose of tivozanib must be taken per day.
The occurrence of undesirable effects may require temporary interruption and/or dose reduction of tivozanib therapy. In the pivotal study, the dose was reduced for grade 3 events and interrupted for grade 4 events.
When dose reduction is necessary, the tivozanib dose can be reduced to 890 microgram once daily with the normal treatment schedule of 21 days of dosing, followed by a 7-day rest period.
In the case of a missed dose a replacement dose must not be taken to make up for a forgotten dose. The next dose should be taken at the next scheduled time.
In the case of vomiting a replacement dose should not be taken; the next dose should be taken at the next scheduled time.
Tivozanib may be taken with or without food.
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