Active Ingredient: Canacinumab
Canakinumab is indicated for the treatment of Familial Mediterranean Fever (FMF). Canakinumab should be given in combination with colchicine, if appropriate.
For this indication, competent medicine agencies globally authorize below treatments:
Subcutaneous
2 - 4 mg per kg of body weight
From 2 To 4 mg per kg of body weight once every 28 day(s)
The recommended starting dose of canakinumab in TRAPS, HIDS/MKD and FMF patients is:
This is administered every four weeks as a single dose via subcutaneous injection.
If a satisfactory clinical response has not been achieved 7 days after treatment start, a second dose of canakinumab at 150 mg or 2 mg/kg can be considered. If a full treatment response is subsequently achieved, the intensified dosing regimen of 300 mg (or 4 mg/kg for patients weighing â€40 kg) every 4 weeks should be maintained.
Continued treatment with canakinumab in patients without clinical improvement should be reconsidered by the treating physician.
The following are suitable injection sites: upper thigh, abdomen, upper arm or buttocks. It is recommended to select a different injection site each time the product is injected to avoid soreness. Broken skin and areas which are bruised or covered by a rash should be avoided. Injection into scar tissue should be avoided as this may result in insufficient exposure to canakinumab.
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