Pulmonary arterial hypertension functional class (FC) II to III

Active Ingredient: Macitentan

Indication for Macitentan

Population group: only adults (18 years old or older)

Therapeutic intent: Curative procedure

Macitentan, as monotherapy or in combination, is indicated for the long-term treatment of pulmonary arterial hypertension (PAH) in adult patients of WHO Functional Class (FC) II to III.

Efficacy has been shown in a PAH population including idiopathic and heritable PAH, PAH associated with connective tissue disorders, and PAH associated with corrected simple congenital heart disease.

For this indication, competent medicine agencies globally authorize below treatments:

10 mg once daily

For:

Dosage regimens

Oral, 10 milligrams macitentan, once daily.

Detailed description

The recommended dose is 10 mg once daily.

If the patient misses a dose of macitentan, the patient should be told to take it as soon as possible and then take the next dose at the regularly scheduled time. The patient should be told not to take two doses at the same time if a dose has been missed.

Dosage considerations

It may be taken with or without food. It should be taken every day at about the same time.

Active ingredient

Macitentan
Macitentan is an orally active potent endothelin receptor antagonist, active on both ET_A and ET_B receptors. Endothelin (ET)-1 and its receptors (ET_A and ET_B) mediate a variety of effects such as vasoconstriction, fibrosis, proliferation, hypertrophy, and inflammation. In disease conditions such as PAH, the local ET system is upregulated and is involved in vascular hypertrophy and in organ damage. Read more about Macitentan

Related medicines

Summary of Product Characteristics (SPC) 2023: OPSUMIT Film-coated tablet

Develop a tailored medication plan for your case, considering factors such as age, gender, and health history

Ask the Reasoner

Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.