Bronchospasm, asthma, bronchitis

Active Ingredient: Ipratropium

Indication for Ipratropium

Population group: only children (1 year - 12 years old)

Ipratropium is indicated, when used concomitantly with inhaled beta2-agonists, for treatment of reversible airways obstruction as in acute and chronic asthma.

For this indication, competent medicine agencies globally authorize below treatments:

500-1000 micrograms in 4 seperated doses daily

Route of admnistration

Respiratory (Inhalation)

Defined daily dose

500 - 1,000 ug

Dosage regimen

From 125 To 250 ug 4 time(s) per day every day

Detailed description

Children 6-12 years of age: 250 micrograms (i.e. one vial of 250 micrograms in 1ml) up to a total daily dose of 1mg (4 vials). The time interval between doses may be determined by the physician.

Children 0–5 years of age (for treatment of acute asthma only): 125–250 micrograms (i.e. half to one vial of 250 micrograms in 1 ml) up to a total daily dose of 1 mg (4 vials). Ipratropium bromide should be administered no more frequently than 6 hourly in children under 5 years of age.

For acute bronchospasm, repeated doses may be administered until the patient is stable.

Active ingredient

Ipratropium

Ipratropium is a quaternary ammonium compound with anticholinergic (parasympatholytic) properties. Ipratropium appears to inhibit vagally mediated reflexes by antagonising the action of acetylcholine, the transmitter agent released from the vagus nerve. Anticholinergics prevent the increase in intracellular concentration of Ca++, which is caused by interaction of acetylcholine with the muscarinic receptor on bronchial smooth muscle. Ca++ release is mediated by the second messenger system consisting of IP3 (inositol triphosphate) and DAG (diacylglycerol).

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