Hereditary angioedema with C1-esterase-inhibitor deficiency

Active Ingredient: Conestat alfa

Indication for Conestat alfa

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Conestat alfa is indicated for treatment of acute angioedema attacks in adolescents, and children (aged 2 years and above) with hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency.

For this indication, competent medicine agencies globally authorize below treatments:

50 U/kg

Route of admnistration

Intravenous

Defined daily dose

50 - 50 [iU] per kg of body weight

Dosage regimen

From 50 To 50 [iU] per kg of body weight once every day

Detailed description

Conestat alfa may be used in paediatric patients (2 years and older) at the same dose as in adults (50 U/kg body weight).

The safety and efficacy of conestat alfa in children less than 2 years old have not been established. No clinical data are available.

Active ingredient

Conestat alfa

Conestat alfa, a recombinant human complement component 1 (C1) esterase inhibitor (rhC1-INH), is an analogue of human C1-INH and is obtained from the milk of rabbits expressing the gene coding for human C1-INH. C1-INH exerts an inhibitory effect on several proteases (target proteases) of the contact and complement systems.

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