Active Ingredient: Nemolizumab
Nemolizumab is indicated for the treatment of moderate-to-severe atopic dermatitis in patients aged 12 years and older who are candidates for systemic therapy.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous, 60 milligrams nemolizumab, one dose. Afterwards, subcutaneous, 30 milligrams nemolizumab, once every 4 weeks, over the duration of 16 weeks. Afterwards, subcutaneous, 30 milligrams nemolizumab, once every 8 weeks.
The recommended dose is:
Nemolizumab can be used with or without topical corticosteroids (TCS). Topical calcineurin inhibitors (TCI) may be used, but should be reserved for problem areas only, such as the face, neck, intertriginous and genital areas. Any use of topical therapies should be tapered and subsequently discontinued when the disease has sufficiently improved.
Consideration should be given to discontinuing treatment in patients who have shown no response after 16 weeks of treatment for atopic dermatitis. Some patients with initial partial response may further improve with continued treatment beyond 16 weeks. Once clinical response is achieved, the recommended maintenance dose of nemolizumab is 30 mg every 8 weeks.
If a dose is missed, it should be administered as soon as possible. Thereafter, dosing should be resumed at the regular scheduled time.
The subcutaneous injection should be administered into the front upper thighs or abdomen avoiding the 5 cm area around the navel. Injection into the upper arm should only be performed by a caregiver or healthcare professional.
For subsequent doses, it is recommended to rotate the injection site with each dose. Nemolizumab should not be injected into skin that is tender, inflamed, swollen, damaged or has bruises, scars or open wounds.
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