Active Ingredient: Ustekinumab
Ustekinumab is indicated for the treatment of moderate to severe plaque psoriasis in adults who failed to respond to, or who have a contraindication to, or are intolerant to other systemic therapies including ciclosporin, methotrexate (MTX) or PUVA (psoralen and ultraviolet A).
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: In case that patient weight is ≤ 100 kg, subcutaneous, 45 milligrams ustekinumab, one dose, over the duration of 4 weeks. Afterwards, in case that patient weight is ≤ 100 kg, subcutaneous, 45 milligrams ustekinumab, one dose, over the duration of 4 weeks. Afterwards, in case that patient weight is ≤ 100 kg, subcutaneous, 45 milligrams ustekinumab, once every 12 weeks.
Regimen B: In case that patient weight is ≥ 100 kg, subcutaneous, 90 milligrams ustekinumab, one dose, over the duration of 4 weeks. Afterwards, in case that patient weight is ≥ 100 kg, subcutaneous, 45 milligrams ustekinumab, one dose, over the duration of 4 weeks. Afterwards, in case that patient weight is ≥ 100 kg, subcutaneous, 45 milligrams ustekinumab, once every 12 weeks.
The recommended posology of ustekinumab is an initial dose of 45 mg administered subcutaneously, followed by a 45 mg dose 4 weeks later, and then every 12 weeks thereafter.
Consideration should be given to discontinuing treatment in patients who have shown no response up to 28 weeks of treatment.
For patients with a body weight >100 kg the initial dose is 90 mg administered subcutaneously, followed by a 90 mg dose 4 weeks later, and then every 12 weeks thereafter. In these patients, 45 mg was also shown to be efficacious. However, 90 mg resulted in greater efficacy.
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