Epithelial ovarian, fallopian tube and primary peritoneal cancer

Active Ingredient: Bevacizumab

Indication for Bevacizumab

Population group: only adults (18 years old or older)
Therapeutic intent: Adjunct intent

Bevacizumab, in combination with carboplatin and paclitaxel is indicated for the front-line treatment of adult patients with advanced (International Federation of Gynecology and Obstetrics (FIGO) stages III B, III C and IV) epithelial ovarian, fallopian tube, or primary peritoneal cancer.

For this indication, competent medicine agencies globally authorize below treatments:

15 mg/kg of body weight once every 3 weeks

For:

Dosage regimens

Intravenous, 15 milligrams bevacizumab per kilogram of body weight, once every 3 weeks.

Detailed description

Front-line treatment

Bevacizumab is administered in addition to carboplatin and paclitaxel for up to 6 cycles of treatment followed by continued use of bevacizumab as single agent until disease progression or for a maximum of 15 months or until unacceptable toxicity, whichever occurs earlier. The recommended dose of bevacizumab is 15 mg/kg of body weight given once every 3 weeks as an intravenous infusion.

Dosage considerations

It should not be administered as an intravenous push or bolus.

Dose reduction for adverse reactions is not recommended. If indicated, therapy should either be permanently discontinued or temporarily suspended.

Active ingredient

Bevacizumab

Bevacizumab binds to vascular endothelial growth factor (VEGF), the key driver of vasculogenesis and angiogenesis, and thereby inhibits the binding of VEGF to its receptors, Flt-1 (VEGFR-1) and KDR (VEGFR-2), on the surface of endothelial cells. Neutralising the biological activity of VEGF regresses the vascularisation of tumours, normalises remaining tumour vasculature, and inhibits the formation of new tumour vasculature, thereby inhibiting tumour growth.

Read more about Bevacizumab

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