Active Ingredient: Quetiapine
For this indication, competent medicine agencies globally authorize below treatments:
Oral
300 - 800 mg
From 300 To 800 mg once every day
50 mg
50 mg should be administrated at least one hour before a meal. The daily dose at the start of therapy is 300 mg on Day 1 and 600 mg on Day 2. The recommended daily dose is 600 mg, however if clinically justified the dose may be increased to 800 mg daily. The dose should be adjusted within the effective dose range of 400 mg to 800 mg per day, depending on the clinical response and tolerability of the patient. For maintenance therapy in schizophrenia no dosage adjustment is necessary.
As with other antipsychotics and antidepressants, quetiapine 50 mg should be used with caution in the elderly, especially during the initial dosing period. The rate of dose titration of quetiapine 50 mg may need to be slower, and the daily therapeutic dose lower, than that used in younger patients. The mean plasma clearance of quetiapine was reduced by 30% to 50% in elderly patients when compared to younger patients. Elderly patients should be started on 50 mg/day. The dose can be increased in increments of 50 mg/day to an effective dose, depending on the clinical response and tolerability of the individual patient.
Should be administrated at least one hour before a meal.
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