Active Ingredient: Oseltamivir
Oseltamivir is indicated in adults and children including full term neonates who present with symptoms typical of influenza, when influenza virus is circulating in the community. Efficacy has been demonstrated when treatment is initiated within two days of first onset of symptoms.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
6 mg per kg of body weight
3 mg per kg of body weight 2 time(s) per day every day for 5 day(s)
The recommended treatment dose for infants 0-12 months of age is 3 mg/kg twice daily. This is based upon pharmacokinetic and safety data indicating that this dose in infants 0-12 months provides plasma concentrations of the pro-drug and active metabolite that are anticipated to be clinically efficacious with a safety profile comparable to that seen in older children and adults.
The following dosing regimen is recommended for treatment of infants 0-12 months of age:
| Body weight* | Recommended dose for 5 days |
|---|---|
| 3 kg | 9 mg twice daily |
| 4 kg | 12 mg twice daily |
| 5 kg | 15 mg twice daily |
| 6 kg | 18 mg twice daily |
| 7 kg | 21 mg twice daily |
| 8 kg | 24 mg twice daily |
| 9 kg | 27 mg twice daily |
| 10 kg | 30 mg twice daily |
* This table is not intended to contain all possible weights for this population. For all patients under the age of 1 year, 3 mg/kg should be used to determine dose regardless of the weight of the patient.
Treatment should be initiated as soon as possible within the first two days of onset of symptoms of influenza.
This dosing recommendation is not intended for premature infants, i.e. those with a post-conceptual age less than 36 weeks. Insufficient data are available for these patients, in whom different dosing may be required due to the immaturity of physiological functions.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.
