Moderate to severe irritable bowel syndrome with constipation (IBS-C)

Active Ingredient: Linaclotide

Indication for Linaclotide

Population group: only adults (18 years old or older)

Linaclotide is indicated for the symptomatic treatment of moderate to severe irritable bowel syndrome with constipation (IBS-C) in adults.

For this indication, competent medicine agencies globally authorize below treatments:

290 ug once daily

Route of admnistration

Oral

Defined daily dose

290 - 290 ug

Dosage regimen

From 290 To 290 ug once every day

Detailed description

The recommended dose is 290 micrograms once daily.

Physicians should periodically assess the need for continued treatment. The efficacy of linaclotide has been established in double-blind placebo-controlled studies for up to 6 months. If patients have not experienced improvement in their symptoms after 4 weeks of treatment, the patient should be re-examined and the benefit and risks of continuing treatment reconsidered.

Dosage considerations

It should be taken at least 30 minutes before a meal.

Active ingredient

Linaclotide

Linaclotide is a Guanylate Cyclase-C receptor agonist (GCCA) with visceral analgesic and secretory activities. Through its action at GC-C, linaclotide has been shown to reduce visceral pain and increase GI transit in animal models and increase colonic transit in humans.

Read more about Linaclotide

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