Advanced and/or metastatic renal cell cancer

Active Ingredient: Bevacizumab

Indication for Bevacizumab

Population group: only adults (18 years old or older)
Therapeutic intent: Adjunct intent

Bevacizumab in combination with interferon alfa-2a is indicated for first-line treatment of adult patients with advanced and/or metastatic renal cell cancer.

For this indication, competent medicine agencies globally authorize below treatments:

10 mg/kg of body weight once every 2 weeks

For:

Dosage regimens

Intravenous, 10 milligrams bevacizumab per kilogram of body weight, once every 2 weeks.

Detailed description

The recommended dose of bevacizumab is 10 mg/kg of body weight given once every 2 weeks as an intravenous infusion.

It is recommended that treatment be continued until progression of the underlying disease or until unacceptable toxicity.

Dosage considerations

The initial dose should be delivered over 90 minutes as an intravenous infusion. If the first infusion is well tolerated, the second infusion may be administered over 60 minutes. If the 60-minute infusion is well tolerated, all subsequent infusions may be administered over 30 minutes.

It should not be administered as an intravenous push or bolus.

Dose reduction for adverse reactions is not recommended. If indicated, therapy should either be permanently discontinued or temporarily suspended.

Bevacizumab infusions should not be administered or mixed with glucose solutions.

Active ingredient

Bevacizumab

Bevacizumab binds to vascular endothelial growth factor (VEGF), the key driver of vasculogenesis and angiogenesis, and thereby inhibits the binding of VEGF to its receptors, Flt-1 (VEGFR-1) and KDR (VEGFR-2), on the surface of endothelial cells. Neutralising the biological activity of VEGF regresses the vascularisation of tumours, normalises remaining tumour vasculature, and inhibits the formation of new tumour vasculature, thereby inhibiting tumour growth.

Read more about Bevacizumab

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