Active Ingredient: Candesartan
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: In case that patient weight is ≤ 50 kg, oral, 4 milligrams candesartan, once daily. Afterwards, in case that patient weight is ≤ 50 kg, oral, between 4 milligrams candesartan and 8 milligrams candesartan, once daily.
Regimen B: In case that patient weight is ≥ 50 kg, oral, 4 milligrams candesartan, once daily. Afterwards, in case that patient weight is ≥ 50 kg, oral, between 4 milligrams candesartan and 16 milligrams candesartan, once daily.
The recommended starting dose is 4 mg once daily.
Doses above 32 mg have not been studied in paediatric patients.
Most of the antihypertensive effect is attained within 4 weeks.
For children with possible intravascular volume depletion (e.g., patients treated with diuretics, particularly those with impaired renal function), candesartan treatment should be initiated under close medical supervision and a lower starting dose than the general starting dose above should be considered.
Candesartan has not been studied in children with glomerular filtration rate less than 30 ml/min/1.73m².
The antihypertensive effect of candesartan is less pronounced in black patients than in nonblack patients.
Candesartan should be taken once daily with or without food.
The bioavailability of candesartan is not affected by food.
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