Plaque psoriasis

Active Ingredient: Risankizumab

Indication for Risankizumab

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Risankizumab is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy.

For this indication, competent medicine agencies globally authorize below treatments:

150 mg once at week 0, week 4, and every 12 weeks thereafter

For:

Dosage regimens

Subcutaneous, 150 milligrams risankizumab, once every 4 weeks, 2 doses in total. Afterwards, subcutaneous, 150 milligrams risankizumab, once every 12 weeks.

Detailed description

The recommended dose is 150 mg administered by subcutaneous injection at week 0, week 4, and every 12 weeks thereafter.

Consideration should be given to discontinuing treatment in patients who have shown no response after 16 weeks of treatment. Some patients with initial partial response may subsequently improve with continued treatment beyond 16 weeks.

Missed dose

If a dose is missed, the dose should be administered as soon as possible. Thereafter, dosing should be resumed at the regular scheduled time.

Dosage considerations

The injection should be administered in the thigh or abdomen. Patients should not inject into areas where the skin is tender, bruised, erythematous, indurated, or affected by psoriasis.

Administration of risankizumab in the upper, outer arm may only be performed by a healthcare professional or caregiver.

Active ingredient

Risankizumab

Risankizumab is a humanised immunoglobulin G1 (IgG1) monoclonal antibody that selectively binds with high affinity to the p19 subunit of human interleukin 23 (IL-23) cytokine without binding to IL-12 and inhibits its interaction with the IL-23 receptor complex. IL-23 is a cytokine that is involved in inflammatory and immune responses. By blocking IL-23 from binding to its receptor, risankizumab inhibits IL-23-dependent cell signalling and release of proinflammatory cytokines.

Read more about Risankizumab

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