Active Ingredient: Evolocumab
Evolocumab is indicated in adults with established atherosclerotic cardiovascular disease (myocardial infarction, stroke or peripheral arterial disease) to reduce cardiovascular risk by lowering LDL-C levels, as an adjunct to correction of other risk factors:
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Subcutaneous, 140 milligrams evolocumab, once every 2 weeks.
Regimen B: Subcutaneous, 420 milligrams evolocumab, once monthly.
The recommended dose of evolocumab is either 140 mg every two weeks or 420 mg once monthly; both doses are clinically equivalent.
Evolocumab is for subcutaneous injection into the abdomen, thigh or upper arm region. Injection sites should be rotated and injections should not be given into areas where the skin is tender, bruised, red, or hard.
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