Prophylaxis of acid aspiration (Mendelson's) syndrome

Active Ingredient: Ranitidine

Indication for Ranitidine

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Preventive action

For this indication, competent medicine agencies globally authorize below treatments:

300 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

300 - 300 mg

Dosage regimen

From 150 To 150 mg 2 time(s) per day every day

Detailed description

150 mg oral dose can be given 2 hours before anaesthesia, and preferably also 150 mg the previous evening. Alternatively, the injection is also available. In obstetric patients in labour 150 mg every 6 hours, but if general anaesthesia is required it is recommended that a non-particulate antacid (e.g. sodium citrate) be given in addition. The usual precautions to avoid acid aspiration should also be taken.

50 mg once

Route of admnistration

Intravenous

Defined daily dose

50 - 50 mg

Dosage regimen

From 50 To 50 mg once every day

Detailed description

In patients considered to be at risk of developing acid aspiration syndrome, ranitidine 50 mg may be given intramuscularly or by slow intravenous injection 45 to 60 minutes before induction of general anaesthesia.

50 mg once

Route of admnistration

Intramuscular

Defined daily dose

50 - 50 mg

Dosage regimen

From 50 To 50 mg once every day

Detailed description

In patients considered to be at risk of developing acid aspiration syndrome, ranitidine 50 mg may be given intramuscularly or by slow intravenous injection 45 to 60 minutes before induction of general anaesthesia.

Active ingredient

Ranitidine

Ranitidine is a specific rapidly acting histamine H2-antagonist. It inhibits basal and stimulated secretion of gastric acid, reducing both the volume and the acid and pepsin content of the secretion. Ranitidine has a relatively long duration of action and so a single 150 mg dose effectively suppresses gastric acid secretion for twelve hours.

Read more about Ranitidine

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