Active Ingredient: Duloxetine
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, between 60 milligrams duloxetine and 120 milligrams duloxetine, once daily. The maximum allowed total dose is 120 milligrams duloxetine daily.
The starting and recommended maintenance dose is 60 mg daily with or without food. Dosages above 60 mg once daily, up to a maximum dose of 120 mg per day administered in evenly divided doses, have been evaluated from a safety perspective in clinical trials. The plasma concentration of duloxetine displays large inter-individual variability. Hence, some patients that respond insufficiently to 60 mg may benefit from a higher dose.
Response to treatment should be evaluated after 2 months. In patients with inadequate initial response, additional response after this time is unlikely.
The therapeutic benefit should be reassessed regularly (at least every three months).
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