Leukemia

Active Ingredient: Thiotepa

Indication for Thiotepa

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

For this indication, competent medicine agencies globally authorize below treatments:

10 mg/kg in 2 divided doses a day

Route of admnistration

Intravenous

Defined daily dose

250 - 250 mg per m² of body surface area (BSA)

Dosage regimen

From 125 To 125 mg per m² of body surface area (BSA) 2 time(s) per day every day

Detailed description

Allogenic haematopoietic progenitor cell transplantation

The recommended dose is 250 mg/m²/day (10 mg/kg/day) divided in two daily infusions, administered before allogeneic HPCT, without exceeding the total maximum cumulative dose of 250 mg/m² (10 mg/kg), during the time of the entire conditioning treatment.

Dosage considerations

Thiotepa must be administered by a qualified healthcare professional as a 2-4 hours intravenous infusion via a central venous catheter.

250 mg/m² in 2 divided doses a day

Route of admnistration

Intravenous

Defined daily dose

10 - 10 mg per kg of body weight

Dosage regimen

From 5 To 5 mg per kg of body weight 2 time(s) per day every day

Detailed description

Allogenic haematopoietic progenitor cell transplantation

The recommended dose is 250 mg/m²/day (10 mg/kg/day) divided in two daily infusions, administered before allogeneic HPCT, without exceeding the total maximum cumulative dose of 250 mg/m² (10 mg/kg), during the time of the entire conditioning treatment.

Dosage considerations

Thiotepa must be administered by a qualified healthcare professional as a 2-4 hours intravenous infusion via a central venous catheter.

Active ingredient

Thiotepa

Thiotepa is a polyfunctional cytotoxic agent related chemically and pharmacologically to the nitrogen mustard. The radiomimetic action of thiotepa is believed to occur through the release of ethylene imine radicals that, as in the case of irradiation therapy, disrupt the bonds of DNA, e.g. by alkylation of guanine at the N-7, breaking the linkage between the purine base and the sugar and liberating alkylated guanine.

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