Active Ingredient: Lamivudine
Lamivudine is indicated as part of antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infected adults.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Oral, 150 milligrams lamivudine, 2 times daily.
Regimen B: Oral, 300 milligrams lamivudine, once daily.
The recommended dose of lamivudine is 300 mg daily. This may be administered as either 150 mg twice daily or 300 mg once daily.
Lamivudine may be administered with or without food.
For:
Regimen A: In case that patient weight is ≥ 25 kg, oral, 150 milligrams lamivudine, 2 times daily.
Regimen B: In case that patient weight is ≥ 25 kg, oral, 300 milligrams lamivudine, once daily.
Regimen C: In case that patient weight is ≥ 20 kg and patient weight is ≤ 25 kg, oral, 225 milligrams lamivudine, divided 2 times daily.
Regimen D: In case that patient weight is ≥ 20 kg and patient weight is ≤ 25 kg, oral, 225 milligrams lamivudine, once daily.
Regimen E: In case that patient weight is ≥ 14 kg and patient weight is ≤ 20 kg, oral, 75 milligrams lamivudine, 2 times daily.
Regimen F: In case that patient weight is ≥ 14 kg and patient weight is ≤ 20 kg, oral, 150 milligrams lamivudine, once daily.
Regimen G: In case that patient age in years is ≥ 1, oral, 5 milligrams lamivudine per kilogram of body weight, 2 times daily.
Regimen H: In case that patient age in years is ≥ 1, oral, 10 milligrams lamivudine per kilogram of body weight, once daily.
Regimen I: In case that patient age in years is ≤ 1, oral, 5 milligrams lamivudine per kilogram of body weight, 2 times daily.
Regimen J: In case that patient age in years is ≤ 1, oral, 10 milligrams lamivudine per kilogram of body weight, once daily.
The recommended dose of lamivudine is 300 mg daily. This may be administered as either 150 mg twice daily or 300 mg once daily.
Children weighing ≥20 kg to <25 kg: The recommended dose is 225 mg daily. This may be administered as either 75 mg taken in the morning and 150 mg taken in the evening, or 225 mg taken once daily.
Children weighing 14 to <20 kg: The recommended dose is 150 mg daily. This may be administered as 75 mg taken twice daily, or 150 mg taken once daily.
Children from three months of age: The limited data available are insufficient to propose specific dosage recommendations.
Children less than three months of age: The limited data available are insufficient to propose specific dosage recommendations.
Children from one year of age: The recommended dose is 5 mg/kg twice daily, or 10 mg/kg once daily.
Children from three months to one year of age: The recommended dose is 5 mg/kg twice daily. If a twice daily regimen is not feasible, a once daily regimen 10 mg/kg/day could be considered. It should be taken into account that data for the once daily regimen are very limited in this population.
Patients changing from the twice daily dosing regimen to the once daily dosing regimen should take the recommended once daily dose (as described above) approximately 12 hours after the last twice daily dose, and then continue to take the recommended once daily dose (as described above) approximately every 24 hours. When changing back to a twice daily regimen, patients should take the recommended twice daily dose approximately 24 hours after the last once daily dose.
Lamivudine may be administered with or without food.
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