Active Ingredient: Bevacizumab
Bevacizumab in combination with fluoropyrimidine-based chemotherapy is indicated for treatment of adult patients with metastatic carcinoma of the colon or rectum.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Intravenous, 5 milligrams bevacizumab per kilogram of body weight, once every 2 weeks.
Regimen B: Intravenous, 10 milligrams bevacizumab per kilogram of body weight, once every 2 weeks.
Regimen C: Intravenous, 7.5 milligrams bevacizumab per kilogram of body weight, once every 3 weeks.
Regimen D: Intravenous, 15 milligrams bevacizumab per kilogram of body weight, once every 3 weeks.
The recommended dose of bevacizumab, administered as an intravenous infusion, is either 5 mg/kg or 10 mg/kg of body weight given once every 2 weeks or 7.5 mg/kg or 15 mg/kg of body weight given once every 3 weeks.
It is recommended that treatment be continued until progression of the underlying disease or until unacceptable toxicity.
It should not be administered as an intravenous push or bolus.
Dose reduction for adverse reactions is not recommended. If indicated, therapy should either be permanently discontinued or temporarily suspended.
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