Parkinson's disease

Active Ingredient: Safinamide

Indication for Safinamide

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Safinamide is indicated for the treatment of adult patients with idiopathic Parkinson’s disease (PD) as addon therapy to a stable dose of levodopa (L-dopa) alone or in combination with other PD medicinal products in mid-to late-stage fluctuating patients.

For this indication, competent medicine agencies globally authorize below treatments:

50-100 mg once daily

For:

Dosage regimens

Oral, between 50 milligrams safinamide and 100 milligrams safinamide, once daily.

Detailed description

Treatment with safinamide should be started at 50 mg per day. This daily dose may be increased to 100 mg/day on the basis of individual clinical need.

If a dose is missed the next dose should be taken at the usual time the next day.

Dosage considerations

Safinamide should be taken with water.

Safinamide may be taken with or without food.

Active ingredient

Safinamide

Safinamide acts through both dopaminergic and non-dopaminergic mechanisms of action. Safinamide is a highly selective and reversible MAO-B inhibitor causing an increase in extracellular levels of dopamine in the striatum. Safinamide is indicated for the treatment of adult patients with idiopathic Parkinson’s disease (PD) as addon therapy to a stable dose of levodopa (L-dopa).

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