Active Ingredient: Corifollitropin alfa
Corifollitropin alfa is indicated for the treatment of adolescent males (14 years and older) with hypogonadotropic hypogonadism, in combination with human Chorionic Gonadotropin (hCG).
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous
100 - 150 ug per kg of body weight
From 100 To 150 ug per kg of body weight once every 14 day(s) for 84 day(s)
In the treatment of adolescent males (14 years and older) with hypogonadotropic hypogonadism, the dose of corifollitropin alfa is based on body weight.
For adolescent males weighing less than or equal to 60 kg:
100 micrograms of corifollitropin alfa once every two weeks for 12 weeks, followed by concomitant administration of corifollitropin alfa (once every 2 weeks) with hCG. For patients initiating therapy with 100 micrograms, consider increasing the dose if their body weight increases to greater than 60 kg during the course of treatment.
For adolescent males weighing more than 60 kg:
150 micrograms of corifollitropin alfa once every two weeks for 12 weeks, followed by concomitant administration of corifollitropin alfa (once every 2 weeks) with hCG.
Combination therapy with hCG twice weekly (500–5000 IU) may be necessary for 52 weeks or longer to achieve adult gonadal development.
There are no data to support safety and efficacy when treatment is used for more than 52 weeks and/or after 17 years of age.
Subcutaneous injection in the abdominal wall may be carried out by the patient or a caregiver, provided they have been appropriately trained. Corifollitropin alfa should be administered once every two weeks, in the morning on the same day of the week in combination with hCG twice weekly (500–5000 IU).
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