Ankylosing spondylitis

Active Ingredient: Etoricoxib

Indication for Etoricoxib

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

Etoricoxib is indicated in adults and adolescents 16 years of age and older for the symptomatic relief of ankylosing spondylitis.

For this indication, competent medicine agencies globally authorize below treatments:

60 mg once daily

For:

Dosage regimens

In case that patient age in years is ≥ 16, oral, 60 milligrams etoricoxib, once daily. The maximum allowed total dose is 90 milligrams etoricoxib daily.

Detailed description

The recommended dose is 60 mg once daily. In some patients with insufficient relief from symptoms, an increased dose of 90 mg once daily may increase efficacy. Once the patient is clinically stabilised, down-titration to a 60 mg once daily dose may be appropriate. In the absence of an increase in therapeutic benefit, other therapeutic options should be considered.

Active ingredient

Etoricoxib

Etoricoxib is an oral, selective cyclo-oxygenase-2 (COX-2) inhibitor within the clinical dose range. Cyclooxygenase is responsible for generation of prostaglandins. Two isoforms, COX-1 and COX-2, have been identified. COX-2 is the isoform of the enzyme that has been shown to be induced by pro-inflammatory stimuli and has been postulated to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. COX-2 is also involved in ovulation, implantation and closure of the ductus arteriosus, regulation of renal function, and central nervous system functions (fever induction, pain perception and cognitive function). It may also play a role in ulcer healing. COX-2 has been identified in tissue around gastric ulcers in man but its relevance to ulcer healing has not been established.

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