Carcinoma of breast

Active Ingredient: Melphalan

Indication for Melphalan

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

0.15 mg/kg once a day for 5 days every six weeks

Route of admnistration

Oral

Defined daily dose

0.15 - 0.15 mg per kg of body weight

Dosage regimen

From 0.15 To 0.15 mg per kg of body weight once every day for 5 day(s)

Detailed description

Melphalan has been given orally at a dose of 0.15 mg/kg bodyweight or 6 mg/m² body surface area/day for 5 days and repeated every 6 weeks. The dose was decreased if bone marrow toxicity was observed.

6 mg/m² body surface area once a day for 5 days every six weeks

Route of admnistration

Oral

Defined daily dose

6 - 6 mg per kg of body weight

Dosage regimen

From 6 To 6 mg per kg of body weight once every day for 5 day(s)

Detailed description

Melphalan has been given orally at a dose of 0.15 mg/kg bodyweight or 6 mg/m² body surface area/day for 5 days and repeated every 6 weeks. The dose was decreased if bone marrow toxicity was observed.

Active ingredient

Melphalan

Melphalan is a bifunctional alkylating agent. Formation of carbonium intermediates from each of the two bis-2-chloroethyl groups enables alkylation through covalent binding with the 7-nitrogen of guanine on DNA, cross-linking the two DNA strands and thereby preventing cell replication.

Read more about Melphalan

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