Antidote for pyrimethamine toxicity

Active Ingredient: Calcium folinate

Indication for Calcium folinate

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

5-50 mg/day simultaneously administered with pyrimethamine

For:

Dosage regimens

Intravenous, in total between 5 milligrams calcium folinate and 50 milligrams calcium folinate, daily.

Detailed description

In cases of high dose pyrimethamine or prolonged treatment with low doses, calcium folinate 5 to 50 mg/day should be simultaneously administered, based on the results of the peripheral blood counts.

5-50 mg/day simultaneously administered with pyrimethamine

For:

Dosage regimens

Intramuscular, in total between 5 milligrams calcium folinate and 50 milligrams calcium folinate, daily.

Detailed description

In cases of high dose pyrimethamine or prolonged treatment with low doses, calcium folinate 5 to 50 mg/day should be simultaneously administered, based on the results of the peripheral blood counts.

Active ingredient

Calcium folinate

Calcium folinate is an active metabolite of folinic acid and essential coenzyme for nucleic acid synthesis in cytotoxic therapy. Calcium folinate is frequently used to diminish the toxicity and counteract the action of folate antagonists, such as methotrexate.

Read more about Calcium folinate

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