Active Ingredient: Rufinamide
Rufinamide is indicated as adjunctive therapy in the treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 1 year of age and older.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
400 - 3,200 mg
From 200 To 1,600 mg 2 time(s) per day every day
400 mg
Treatment should be initiated at a daily dose of 400 mg. According to clinical response and tolerability, the dose may be increased by 400 mg/day increments, as frequently as every other day, up to a maximum recommended dose as indicated in the table below.
| Weight range | 30.0–50.0 kg | 50.1–70.0 kg | ≥70.1 kg |
| Maximum recommended dose | 1,800 mg/day | 2,400 mg/day | 3,200 mg/day |
Doses of up to 4,000 mg/day (in the 30-50 kg range) or 4,800 mg/day (in the over 50 kg) have been studied in a limited number of patients.
Treatment should be initiated at a daily dose of 400 mg. According to clinical response and tolerability, the dose may be increased by 400 mg/day increments, as frequently as every other day, up to a maximum recommended dose as indicated in the table below.
| Weight range | 30.0–50.0 kg | 50.1–70.0 kg | ≥70.1 kg |
| Maximum recommended dose | 1,200 mg/day | 1,600 mg/day | 2,200 mg/day |
Rufinamide should be administered with food.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.
