Active Ingredient: Golimumab
Golimumab, in combination with methotrexate (MTX), is indicated for:
Golimumab, in combination with MTX, has been shown to reduce the rate of progression of joint damage as measured by X-ray and to improve physical function.
For this indication, competent medicine agencies globally authorize below treatments:
Subcutaneous
50 - 50 mg
From 50 To 50 mg once every 30 day(s)
Golimumab 50 mg given once a month, on the same date each month. Golimumab should be given concomitantly with MTX.
For all of the above indications, available data suggest that clinical response is usually achieved within 12 to 14 weeks of treatment (after 3-4 doses). Continued therapy should be reconsidered in patients who show no evidence of therapeutic benefit within this time period.
For all of the above indications, in patients with RA, PsA, AS, or nr-Axial SpA with a body weight of more than 100 kg who do not achieve an adequate clinical response after 3 or 4 doses, increasing the dose of golimumab to 100 mg once a month may be considered, taking into account the increased risk of certain serious adverse reactions with the 100 mg dose compared with the 50 mg dose. Continued therapy should be reconsidered in patients who show no evidence of therapeutic benefit after receiving 3 to 4 additional doses of 100 mg.
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