Active Ingredient: Risankizumab
Risankizumab is indicated for the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response to, lost response to, or were intolerant to conventional therapy or a biologic therapy.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Intravenous, 1,200 milligrams risankizumab, once every 4 weeks, 3 doses in total, over the duration of 12 weeks. Afterwards, in case that there is very good treatment response, subcutaneous, 180 milligrams risankizumab, once every 8 weeks.
Regimen B: Intravenous, 1,200 milligrams risankizumab, once every 4 weeks, 3 doses in total, over the duration of 12 weeks. Afterwards, in case that there is poor response to treatment, subcutaneous, 360 milligrams risankizumab, once every 8 weeks.
The recommended induction dose is 1 200 mg administered by intravenous infusion at week 0, week 4, and week 8. Starting at week 12 and every 8 weeks thereafter, the recommended maintenance dose is based on individual patient presentation:
Consideration should be given to discontinuing treatment in patients who have shown no evidence of therapeutic benefit by week 24.
Intravenous infusion: The 1 200 mg dose should be administered over at least two hours.
Subcutaneous injection: The injection should be administered in the thigh or abdomen. Risankizumab should not be injected into areas where the skin is tender, bruised, erythematous, indurated or damaged.
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