Gastro-entero-pancreatic endocrine tumours

Active Ingredient: Octreotide

Indication for Octreotide

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

0.1-0.6 mg in 1-3 divided doses daily

Route of admnistration

Subcutaneous

Defined daily dose

0.1 - 0.6 mg

Dosage regimen

From 0.1 To 0.6 mg once every day

Loading dose

0.15 mg

Detailed description

Initially 0.05 mg once or twice daily by s.c. injection. Depending on clinical response, effect on levels of tumour-produced hormones (in cases of carcinoid tumours, on the urinary excretion of 5-hydroxyindole acetic acid), and on tolerability, dosage can be gradually increased to 0.1 to 0.2 mg 3 times daily. Under exceptional circumstances, higher doses may be required. Maintenance doses have to be adjusted individually.

In carcinoid tumours, if there is no beneficial response within 1 week of treatment with octreotide at the maximum tolerated dose, therapy should not be continued.

Dosage considerations

Octreotide may be administered directly by subcutaneous (s.c.) injection or by intravenous (i.v.) infusion after dilution.

Active ingredient

Octreotide

Octreotide is a synthetic octapeptide derivative of naturally occurring somatostatin with similar pharmacological effects, but with a considerably prolonged duration of action. It inhibits pathologically increased secretion of growth hormone (GH) and of peptides and serotonin produced within the GEP endocrine system.

Read more about Octreotide

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