Active Ingredient: Secukinumab
Secukinumab is indicated for the treatment of active ankylosing spondylitis in adults who have responded inadequately to conventional therapy.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous, 150 milligrams secukinumab, once weekly, 5 doses in total. Afterwards, subcutaneous, between 150 milligrams secukinumab and 300 milligrams secukinumab, once monthly.
The recommended dose is 150 mg by subcutaneous injection with initial dosing at weeks 0, 1, 2, 3 and 4, followed by monthly maintenance dosing. Based on clinical response, the dose can be increased to 300 mg. Each 300 mg dose is given as one subcutaneous injection of 300 mg or as two subcutaneous injections of 150 mg.
Available data suggest that a clinical response is usually achieved within 16 weeks of treatment. Consideration should be given to discontinuing treatment in patients who have shown no response by 16 weeks of treatment. Some patients with an initial partial response may subsequently improve with continued treatment beyond 16 weeks.
Secukinumab is to be administered by subcutaneous injection. If possible, areas of the skin that show psoriasis should be avoided as injection sites.
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