Active Ingredient: Olanzapine
Olanzapine is indicated for the treatment of moderate to severe manic episode.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
5 - 20 mg
From 5 To 20 mg once every day
5 mg
A lower starting dose (5 mg/day) is not routinely indicated but should be considered for those 65 and over when clinical factors warrant.
The starting dose is 15 mg as a single daily dose in monotherapy or 10 mg daily in combination therapy.
During treatment for schizophrenia, manic episode and recurrence prevention in bipolar disorder, daily dosage may subsequently be adjusted on the basis of individual clinical status within the range 5-20 mg/day. An increase to a dose greater than the recommended starting dose is advised only after appropriate clinical reassessment and should generally occur at intervals of not less than 24 hours. Olanzapine can be given without regards for meals as absorption is not affected by food. Gradual tapering of the dose should be considered when discontinuing olanzapine.
Olanzapine can be given without regards for meals as absorption is not affected by food.
Intramuscular
2.5 - 20 mg
From 2.5 To 20 mg once every day
2.5 mg
For intramuscular use. Do not administer intravenously or subcutaneously. Olanzapine powder for solution for injection is intended for short term use only, for up to a maximum of three consecutive days.
The recommended starting dose in elderly patients (>60 years) is 2.5-5 mg. Depending on the patient’s clinical status, a second injection, 2.5-5 mg, may be administered 2 hours after the first injection.
Not more than 3 injections should be given in any 24 hour period and the maximum daily dose of 20 mg (including all formulations) of olanzapine should not be exceeded.
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