Active Ingredient: Clobazam
Benzodiazepines are only indicated when the disorder is severe, disabling or subjecting the individual to extreme distress.
In patients with depression or anxiety associated with depression, clobazam must be used only in conjunction with adequate concomitant treatment.
Before treatment of anxiety states associated with emotional instability, it must first be determined whether the patient suffers from a depressive disorder requiring adjunctive or different treatment.
In patients with schizophrenic or other psychotic illnesses, use of benzodiazipines is recommended only for adjunctive, i.e. not for primary treatment.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Oral, between 20 milligrams clobazam and 30 milligrams clobazam, divided daily, over the duration of 8 to 12 weeks.
Regimen B: Oral, between 20 milligrams clobazam and 30 milligrams clobazam, once daily at the end of the day, over the duration of 8 to 12 weeks.
Treatment should be as short as possible. The patient must be re-assessed after a period not exceeding 4 weeks and regularly thereafter in order to evaluate the need for continued treatment, especially where the patient is free of symptoms. Generally the overall duration of treatment (i.e. including tapering-off process) must not exceed 8 to 12 weeks.
In certain cases extension beyond the maximum treatment period may be necessary; if so it should not take place without re-evaluation of the patient’s status with special expertise. It is strongly recommended that prolonged periods of uninterrupted treatment be avoided, since they may lead to dependance.
The usual anxiolytic dose for adults is 20-30 mg daily in divided doses or as a single dose given at night. Doses of up to 60 mg daily have been used in the treatment of adult in-patients with severe anxiety.
The lowest dose that can control symptoms should be used. After improvement of symptoms the dose may be reduced. It should not be used for longer than 4 weeks.
Due regard must be paid to the possibility of interference with alertness and reaction time.
Long term chronic use as an anxiolytic is not recommended. Treatment should always be withdrawn gradually. Patients who have taken clobazam for a long time may require a longer period during which doses are reduced.
Clobazam can be given with or without food.
For:
Oral, between 10 milligrams clobazam and 15 milligrams clobazam, divided daily, over the duration of 8 to 12 weeks.
Treatment should be as short as possible. The patient must be re-assessed after a period not exceeding 4 weeks and regularly thereafter in order to evaluate the need for continued treatment, especially where the patient is free of symptoms. Generally the overall duration of treatment (i.e. including tapering-off process) must not exceed 8 to 12 weeks.
In certain cases extension beyond the maximum treatment period may be necessary; if so it should not take place without re-evaluation of the patient’s status with special expertise. It is strongly recommended that prolonged periods of uninterrupted treatment be avoided, since they may lead to dependance.
Doses of 10-20 mg daily in anxiety may be used in the elderly and debilitated who are usually more sensitive to the effects of psychoactive agents. Treatment requires low initial doses and gradual dose increments under careful observation.
Clobazam can be given with or without food.
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