Active Ingredient: Olaparib
Olaparib is indicated as monotherapy for the maintenance treatment of adult patients with platinum-sensitive relapsed high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete or partial) to platinum-based chemotherapy.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 300 milligrams olaparib, 2 times daily.
The recommended dose of olaparib is 300 mg taken twice daily, equivalent to a total daily dose of 600 mg.
Patients with platinum-sensitive relapsed (PSR) high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete or partial) to platinum-based chemotherapy should start treatment with olaparib no later than 8 weeks after completion of their final dose of the platinum-containing regimen.
If a patient misses a dose of olaparib, they should take their next normal dose at its scheduled time.
Treatment may be interrupted to manage adverse reactions such as nausea, vomiting, diarrhoea, and anaemia and dose reduction can be considered.
The recommended dose reduction is to 250 mg twice daily (equivalent to a total daily dose of 500 mg).
If a further dose reduction is required, then reduction to 200 mg twice daily (equivalent to a total daily dose of 400 mg) is recommended.
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