Reversal of respiratory and other CNS depression in the neonate whose mothers have received opioids

Active Ingredient: Naloxone

Indication for Naloxone

Population group: only newborns (0 - 40 days old)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

0.01 mg/kg and if the desired clinical response is not achieved, repeat every 2-3 min

For:

Dosage regimens

Intravenous, 0.01 milligrams naloxone per kilogram of body weight, once every 2 to 3 minutes.

Detailed description

The usual dosage is 0.01 mg naloxone hydrochloride per kg i.v. If the respiratory function is not reversed to a satisfactory level with this dosage, the injection can be repeated at 2 to 3 minute intervals.

0.01 mg/kg and if the desired clinical response is not achieved, repeat every 2-3 min

For:

Dosage regimens

Intramuscular, 0.01 milligrams naloxone per kilogram of body weight, once every 2 to 3 minutes.

Detailed description

The usual dosage is 0.01 mg naloxone hydrochloride per kg i.v. If i.v. administration is not possible, Naloxone 400 micrograms/ml can also be injected i.m. (initial dose 0.01 mg/kg).

If the respiratory function is not reversed to a satisfactory level with this dosage, the injection can be repeated at 2 to 3 minute intervals.

Active ingredient

Naloxone

Naloxone hydrochloride, a semisynthetic morphine derivative (N-allyl-nor-oxymorphone), is a specific opioid antagonist that acts competitively at opioid receptors. It reveals very high affinity for the opioid receptor sites and therefore displaces both opioid agonists and partial antagonists, such as pentazocine, for example, but also nalorphine.

Read more about Naloxone

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