Acute coronary syndrome

Active Ingredient: Enoxaparin

Indication for Enoxaparin

Population group: only elderly (65 years old or older)

Acute coronary syndrome:

  • Treatment of unstable angina and Non ST-segment elevation myocardial infarction (NSTEMI), in combination with oral acetylsalicylic acid.
  • Treatment of acute ST-segment elevation myocardial infarction (STEMI) including patients to be managed medically or with subsequent percutaneous coronary intervention (PCI).

For this indication, competent medicine agencies globally authorize below treatments:

150 IU/kg in 2 divided doses daily

Route of admnistration

Subcutaneous

Defined daily dose

150 - 150 [iU] per kg of body weight

Dosage regimen

From 75 To 75 [iU] per kg of body weight 2 time(s) per day every day

Detailed description

For treatment of acute STEMI in elderly patients ≥75 years of age, an initial IV bolus must not be used. Initiate dosing with 75 IU/kg (0.75 mg/kg) SC every 12 hours (maximum 7,500 IU (75 mg) for each of the first two SC doses only, followed by 75 IU/kg (0.75 mg/kg) SC dosing for the remaining doses).

1.5 mg/kg in 2 divided doses daily

Route of admnistration

Subcutaneous

Defined daily dose

1.5 - 1.5 mg per kg of body weight

Dosage regimen

From 0.75 To 0.75 mg per kg of body weight 2 time(s) per day every day

Detailed description

For treatment of acute STEMI in elderly patients ≥75 years of age, an initial IV bolus must not be used. Initiate dosing with 75 IU/kg (0.75 mg/kg) SC every 12 hours (maximum 7,500 IU (75 mg) for each of the first two SC doses only, followed by 75 IU/kg (0.75 mg/kg) SC dosing for the remaining doses).

Active ingredient

Enoxaparin

Enoxaparin is a LMWH with a mean molecular weight of approximately 4,500 daltons, in which the antithrombotic and anticoagulant activities of standard heparin have been dissociated. The drug substance is the sodium salt and has a high anti-Xa activity.

Read more about Enoxaparin

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