Metastatic pancreatic cancer

Active Ingredient: Erlotinib

Indication for Erlotinib

Population group: only adults (18 years old or older)

Erlotinib in combination with gemcitabine is indicated for the treatment of patients with metastatic pancreatic cancer.

For this indication, competent medicine agencies globally authorize below treatments:

100 mg once a day

Route of admnistration

Oral

Defined daily dose

100 - 100 mg

Dosage regimen

From 100 To 100 mg once every day

Detailed description

The recommended daily dose of erlotinib is 100 mg taken at least one hour before or two hours after the ingestion of food, in combination with gemcitabine (see the summary of product characteristics of gemcitabine for the pancreatic cancer indication). In patients who do not develop rash within the first 4-8 weeks of treatment, further erlotinib treatment should be re-assessed.

Dosage considerations

Should be taken at least one hour before or two hours after the ingestion of food.

Active ingredient

Erlotinib

Erlotinib is an epidermal growth factor receptor/human epidermal growth factor receptor type 1 (EGFR also known as HER1) tyrosine kinase inhibitor. Erlotinib potently inhibits the intracellular phosphorylation of EGFR. EGFR is expressed on the cell surface of normal cells and cancer cells. Due to the blocking of downstream-signaling, the proliferation of cells is stopped, and cell death is induced through the intrinsic apoptotic pathway.

Read more about Erlotinib

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