Active Ingredient: Quetiapine
Add-on treatment of major depressive episodes in patients with Major Depressive Disorder (MDD) who have had suboptimal response to antidepressant monotherapy.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
50 - 300 mg
From 50 To 300 mg once every day
As with other antipsychotics and antidepressants, Quetiapine 50 mg should be used with caution in the elderly, especially during the initial dosing period. The rate of dose titration of Quetiapine 50 mg may need to be slower, and the daily therapeutic dose lower, than that used in younger patients. The mean plasma clearance of quetiapine was reduced by 30% to 50% in elderly patients when compared to younger patients. Elderly patients should be started on 50 mg/day. The dose can be increased in increments of 50 mg/day to an effective dose, depending on the clinical response and tolerability of the individual patient.
In elderly patients with major depressive episodes in MDD, dosing should begin with 50 mg/day on Days 1-3, increasing to 100 mg/day on Day 4 and 150 mg/day on Day 8. The lowest effective dose, starting from 50 mg/day should be used. Based on individual patient evaluation, if dose increase to 300 mg/day is required this should not be prior to Day 22 of treatment.
Should be administered at bedtime.
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