Active Ingredient: Hemin
Treatment of acute attacks of hepatic porphyria (acute intermittent porphyria, porphyria variegata, hereditary coproporphyria).
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
3 - 3 mg per kg of body weight
From 3 To 3 mg per kg of body weight once every day for 4 day(s)
The recommended daily dose is 3 mg/kg once daily for four days, diluted in 100 ml of 0.9% sodium chloride in a glass bottle and infused intravenously over at least 30 minutes into a large antebrachial or central vein using an inline filter.
The dose should not exceed 250 mg per day.
Exceptionally, the course of the treatment may be repeated under strict biochemical surveillance if there is inadequate response after the first course of treatment.
The infusions should be administered in a large antebrachial or central vein over a period of at least 30 minutes. After the infusion, the vein should be rinsed with 100 ml of 0.9% NaCl. It is recommended to flush the vein initially with 3 to 4 bolus injections of 10 ml 0.9% NaCl after which the remaining volume of saline can be infused for 10-15 minutes.
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