Non-muscle invasive bladder cancer with carcinoma in situ

Active Ingredient: Nadofaragene firadenovec

Indication for Nadofaragene firadenovec

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Nadofaragene firadenovec is indicated for the treatment of adult patients with high-risk Bacillus Calmette-Guérin (BCG)-unresponsive non-Muscle Invasive Bladder Cancer (NMIBC) with carcinoma in situ (CIS) with or without papillary tumors.

For this indication, competent medicine agencies globally authorize below treatments:

295 x 10¹¹ viral particles once every 3 months

For:

Dosage regimens

Intravesical, 29,500,000,000,000 viral particles nadofaragene firadenovec, once every 3 months.

Detailed description

The recommended dose of nadofaragene firadenovec 295 × 1011 viral particles (vp) instilled once every three (3) months into the bladder via a urinary catheter.

Premedication with an anticholinergic is recommended before each instillation of nadofaragene firadenovec.

Active ingredient

Nadofaragene firadenovec

Nadofaragene firadenovec is a non-replicating adenoviral vector-based gene therapy designed to deliver a copy of a gene encoding a human interferon-alfa 2b (IFNα2b) to the bladder urothelium. Intravesical instillation of nadofaragene firadenovec results in cell transduction and transient local expression of the IFNα2b protein that is anticipated to have anti-tumor effects.

Read more about Nadofaragene firadenovec

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