Active Ingredient: Alefacept
Alefacept is indicated is indicated for the treatment of adult patients with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy.
For this indication, competent medicine agencies globally authorize below treatments:
Intramuscular
15 mg
15 mg once every 7 day(s) for 84 day(s)
The recommended dose of alefacept is 15 mg given once weekly as an intramuscular IM injection. The recommended regimen is a course of 12 weekly injections. Retreatment with an additional 12-week course may be initiated provided that CD4+ T lymphocyte counts are within the normal range, and a minimum of a 12-week interval has passed since the previous course of treatment.
The CD4+ T lymphocyte counts of patients receiving alefacept should be monitored before initiating dosing and every two weeks throughout the course of the 12-week dosing regimen. If CD4+ T lymphocyte counts are below 250 cells/µL, Alefacept dosing should be withheld and weekly monitoring instituted. Alefacept should be discontinued if the counts remain below 250 cells/µL for one month
Intravenous
7.5 mg
7.5 mg once every 7 day(s)
The recommended dose of alefacept is 7.5 mg given once weekly as an IV bolus. The recommended regimen is a course of 12 weekly injections. Retreatment with an additional 12-week course may be initiated provided that CD4+ T lymphocyte counts are within the normal range, and a minimum of a 12-week interval has passed since the previous course of treatment.
The CD4+ T lymphocyte counts of patients receiving alefacept should be monitored before initiating dosing and every two weeks throughout the course of the 12-week dosing regimen. If CD4+ T lymphocyte counts are below 250 cells/µL, alefacept dosing should be withheld and weekly monitoring instituted. alefacept should be discontinued if the counts remain below 250 cells/µL for one month.
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