Moderate to severe plaque psoriasis

Active Ingredient: Deucravacitinib

Indication for Deucravacitinib

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Deucravacitinib is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy.

For this indication, competent medicine agencies globally authorize below treatments:

6 mg once daily

For:

Dosage regimens

Oral, 6 milligrams deucravacitinib, once daily.

Detailed description

The recommended dose is 6 mg taken orally once daily.

If a patient shows no evidence of therapeutic benefit after 24 weeks, treatment discontinuation should be considered. The patient’s response to treatment should be evaluated on a regular basis.

Elderly

No dose adjustment is required in elderly patients aged 65 years and older. Clinical experience in patients ≥75 years is very limited and deucravacitinib should be used with caution in this group of patients.

Dosage considerations

It can be taken with or without food.

Active ingredient

Deucravacitinib

Deucravacitinib selectively inhibits the TYK2 enzyme (TYK2 belongs to the JAK family). TYK2 mediates signalling of interleukin-23 (IL-23), interleukin-12 (IL-12), and type I interferons (IFN), which are naturally occurring cytokines involved in inflammatory and immune responses. Deucravacitinib inhibits the release of proinflammatory cytokines and chemokines.

Read more about Deucravacitinib

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