Active Ingredient: Ulinastatin
The diagnosis of mild and severe acute pancreatitis requires 2 of the following 3 features: 1) upper abdominal pain of acute onset often radiating through to the back, 2) serum amylase or lipase activity greater than 3 times normal, and 3) findings on cross-sectional abdominal imaging consistent with acute pancreatitis. In the early phase, which lasts only a week or so, the systemic manifestations are related to the host response to the cytokine cascade, which manifests as SIRS and/or the compensatory anti-inflammatory syndrome (CARS) that can predispose to infection. When SIRS or CARS persist, organ failure sets in. The late phase of acute pancreatitis, which can persist for weeks to months, is characterized by systemic signs of ongoing inflammation, local and systemic complications, and/or by transient or persistent organ failure.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, between 100,000 international units ulinastatin and 200,000 international units ulinastatin, 1 to 3 times daily, over the duration of 3 to 5 days.
Administer 100,000 to 200,000 I.U. of ulinastatin by intravenous infusion over 1 hour each time, 1-3 times per day for 3 to 5 days. The dosage may be adjusted according to the age of patients and the severity of symptoms.
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