Active Ingredient: Vedolizumab
Vedolizumab is indicated for the treatment of adult patients with moderately to severely active chronic pouchitis, who have undergone proctocolectomy and ileal pouch anal anastomosis for ulcerative colitis, and have had an inadequate response with or lost response to antibiotic therapy
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, 300 milligrams vedolizumab, one dose, over the duration of 2 weeks. Afterwards, intravenous, 300 milligrams vedolizumab, one dose, over the duration of 4 weeks. Afterwards, intravenous, 300 milligrams vedolizumab, one dose, over the duration of 8 weeks. Afterwards, intravenous, 300 milligrams vedolizumab, once every 8 weeks.
The recommended dose regimen of intravenous vedolizumab is 300 mg administered by intravenous infusion at 0, 2 and 6 weeks and then every 8 weeks thereafter.
Treatment with vedolizumab should be initiated in parallel with standard of care antibiotic (e.g., fourweek of ciprofloxacin).
Discontinuation of treatment should be considered if no evidence of therapeutic benefit is observed by 14 weeks of treatment with vedolizumab.
There are no retreatment data available in patients with pouchitis.
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