Active Ingredient: Duloxetine
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Oral, 30 milligrams duloxetine, once daily, over the duration of 2 to 4 weeks. Afterwards, oral, between 30 milligrams duloxetine and 60 milligrams duloxetine, once daily. The maximum allowed total dose is 120 milligrams duloxetine daily.
Regimen B: In case that there is major depressive disorder, oral, 60 milligrams duloxetine, once daily. The maximum allowed total dose is 120 milligrams duloxetine daily.
The recommended starting dose in patients with generalised anxiety disorder is 30 mg once daily with or without food. In patients with insufficient response the dose should be increased to 60 mg, which is the usual maintenance dose in most patients.
In patients with co-morbid major depressive disorder, the starting and maintenance dose is 60 mg once daily (please see also dosing recommendation above).
Doses up to 120 mg per day have been shown to be efficacious and have been evaluated from a safety perspective in clinical trials. In patients with insufficient response to 60 mg, escalation up to 90 mg or 120 mg may therefore be considered. Dose escalation should be based upon clinical response and tolerability.
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