Hypokalemia

Route of administration: Intravenous, after dilution.

Before administering Sterile Potassium Chloride Concentrate:

1. This solution must be diluted with not less than 50 times its volume of sodium chloride solution or other suitable diluent.
2. The solution should be carefully mixed with the infusion fluid.

During administration:

1. The diluted injection should be administered by slow intravenous infusion at a maximal rate of 20mmol of potassium per hour.
2. The ECG should be monitored continuously.

The goal of potassium replacement therapy is to elevate the plasma concentration of the ion to within the normal range.

Dose per hour: The maximal rate of intravenous infusion is 20mmol/hour.

Dose per day: Since the normal dietary intake of potassium is 50 to 100mmol daily, it is rare that a larger amount is required during potassium replacement therapy.

If serum potassium concentration is less than 2.5 mEq/L, use intravenous potassium instead of oral supplementation.

Monitoring

Monitor serum potassium and adjust dosages accordingly. Monitor serum potassium periodically during maintenance therapy to ensure potassium remains in desired range.

The treatment of potassium depletion, particularly in the presence of cardiac disease, renal disease, or acidosis, requires careful attention to acid-base balance, volume status, electrolytes, including magnesium, sodium, chloride, phosphate, and calcium, electrocardiograms, and the clinical status of the patient. Correct volume status, acid-base balance, and electrolyte deficits as appropriate.

Administration

Take potassium with meals and with a glass of water or other liquid. Do not take potassium on an empty stomach because of its potential for gastric irritation.

Swallow tablets whole without crushing, chewing or sucking.

Dosing

Dosage must be adjusted to the individual needs of each patient. Dosages greater than 40 mEq per day should be divided such that no more than 40 mEq is given in a single dose.

Treatment of Hypokalemia: Typical dose range is 40 to 100 mEq per day.

Maintenance or Prophylaxis: Typical dose range is 20 mEq per day.

Take potassium with meals and with a glass of water or other liquid. Do not take potassium on an empty stomach because of its potential for gastric irritation.