Syphilis

Active Ingredient: Ceftriaxone

Indication for Ceftriaxone

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old)

For this indication, competent medicine agencies globally authorize below treatments:

75-100 mg/kg once daily

Route of admnistration

Intravenous

Defined daily dose

75 - 100 mg per kg of body weight

Dosage regimen

From 75 To 100 mg per kg of body weight once every day for 10 day(s)

Detailed description

The generally recommended doses are 75-100 mg/kg (max 4 g) once daily for 10-14 days. The dose recommendations in syphilis, including neurosyphilis, are based on very limited data. National or local guidance should be taken into consideration.

Dosage considerations

Ceftriaxone can be administered by intravenous infusion over at least 30 minutes (preferred route) or by slow intravenous injection over 5 minutes. Intravenous intermittent injection should be given over 5 minutes preferably in larger veins.

80-100 mg/kg once daily

Route of admnistration

Intramuscular

Defined daily dose

75 - 100 mg per kg of body weight

Dosage regimen

From 75 To 100 mg per kg of body weight once every day for 10 day(s)

Detailed description

The generally recommended doses are 75-100 mg/kg (max 4 g) once daily for 10-14 days. The dose recommendations in syphilis, including neurosyphilis, are based on very limited data. National or local guidance should be taken into consideration.

Dosage considerations

Intramuscular injections should be injected well within the bulk of a relatively large muscle and not more than 1 g should be injected at one site. Dosages greater than 1g should be divided and injected at more than one site.

Active ingredient

Ceftriaxone

Ceftriaxone is an antibacterial for systemic use, a third-generation cephalosporin. It inhibits bacterial cell wall synthesis following attachment to penicillin binding proteins (PBPs) leading to bacterial cell lysis and death.

Read more about Ceftriaxone

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